缺氧诱导因子-1与乳腺癌的研究进展

Research avancement of breast cancer and hypoxia-inducible factor-1

缺氧诱导因子-1(hypoxia-inducible factor-1,HIF-1)定位于人类染色体14q21-q24,由HIF-1α和HIF-1β两个亚基组成。通过与靶基因HRE(hypoxia response element,低氧反应性元件)结合,促进其转录,引起一系列细胞对缺氧的反应。HIF-1在乳腺癌中表达,并与乳腺癌常见预后及预测因子存在相关性。HIF-1作为一种细胞因子将成为现代乳腺癌评价预后的一个新指标及治疗的一个新靶点。

The hypoxia-inducible factor-1（HIF-1） gene located on the long （q） arm 21-24 of chromosome 14, is composed of HIF-1α and HIF-1β subunits. HIF-1 promotes its target gene HRE to transcribe by binding to the element and then causes a series of responses of the cell to hypoxia. HIF-1 has been found to be overexpressed in breast cancer cell, and the expressions of HIF-1 level were correlated with the prognosis and prediction factors of breast cancer. As a cytokine, HIF-1 will be a new prognosis factor and a new target for the treatment of breast cancer.