胰岛素强化治疗纠正初诊2型糖尿病高血糖状态的临床观察

Clinical observation on correcting hyperglycemia of newly diagnosed type 2 diabetes with intensive insulin treatment

【目的】观察两种胰岛素强化治疗方法对纠正初诊2型糖尿病(type 2 diabetes mellitus,T2DM)高血糖状态的疗效以及剂量。【方法】84例初诊T2DM患者随机分为胰岛素泵(CSII)组及多次胰岛素注射(MSII)组,给予强化治疗,不合用其他口服降糖药,观察达到满意血糖控制(FBG<7 mmol/L,2 hBG<10 mmol/L)的天数及剂量。【结果】两组均显示出明显的降糖效果,两组间比较,血糖达标时间及胰岛素用量的差异有统计学意义(P<0.01);血糖控制满意后,胰岛素用量显著减少。【结论】对初诊T2DM患者,胰岛素泵治疗和多次胰岛素注射治疗均能达到快速稳定控制血糖的目的,从而改善胰腺β细胞功能,但胰岛素泵治疗可以使血糖得到更快的控制。

[Objective] To study the impact of two methods of intensive insulin treatment on the effect of plasma glucose and insulin dosage in newly diagnosed type 2 diabetic patients. [Methods] Eighty-four newly diagnosed type 2 diabetic patients were divided into two groups randomly. They were treated respectively by continuous subcutaneous insulin injection （CSII） and multiple subcutaneous insulin injection （MSII）, without oral hypoglycemic agents. The days when blood glucose was well controlled and the insulin dosage at that time were recorded. [Results] The excellent control of glycose was achieved in both groups . The time and the insulin dosage of glucose up to grade had significant difference （P 〈 0. 01）. The dosage of insulin was decreased after blood glucose were well controlled . [Conclusions] The CSII and MSII treatments can equally achieve the excellent glycemic control in newly diagnosed type 2 diabetic patients . But CSII group could receive faster control on blood glucose than MSII group.