川芎嗪治疗新生儿缺氧缺血性脑病临床研究

Clinical Study of TMP in the Treatment of 45 Cases of HIE

目的观察川芎嗪(TMP)对新生儿缺氧缺血性脑病(HIE)的治疗作用。方法将我院新生儿重症监护室(NICU)收治的(HIE)患儿88例,随机分为治疗组45例,治疗组43例,两组均采用支持、对症处理,治疗组在综合治疗基础上加用TMP治疗14 d。两组分别于治疗前、治疗后14 d测血清CK-BB,同时记录两组症状、体征持续时间及治疗3 d、7 d、14 d后NBNA评分情况。结果两组治疗前后CK-BB及症状恢复时间和NBNA评分情况有显著差异。结论TMP对HIE有显著的治疗作用,值得临床推广应用。

Objeclive To observe the cure effects of TMP on the HIE. Methods To divide treatment group owning 45 cases and contrast group owning 43 examples from 88 HIE sufferers at random who are treated in our hospital＇s NICU during the periods. These two groups all adopt supporting means and suit the remedy to the case. Meanwhile,treating group add TMP for14 days. The amount of serum CK - BB were measured before and after treatment for 14 days respectively, at the same time, the duration of symptoms, signs were observed; the NBNA score were recorded after treatment of three days, seven days, fourteen days. Result There are obvious diferrence between the two groups in the CK - BB, duration of symptoms, signs and NBNA score. Conclusion TMP have positive effects on HIE.