核因子-κB激活在急性重症胰腺炎发病中的作用

Rapid detection of nuclear factor κB activity in patients with severe acute pancreatitis

目的:探讨核因子-κB激活在急性胰腺炎患者血液中的表达与时间关系。方法:急性胰腺炎患者40例,对照组40例,采用流式细胞术检测外周血中核因子-κB激活。结果:胰腺炎组各时段(<24h、24～48h、48～72h、>72h核因子-κB激活明显高于对照组(P<0.01)。24h内核因子-κB明显激活;24～48h达高峰,48h以后逐渐减弱,1周后核因子-κB激活向正常水平接近。对照组各时段核因子-κB激活不明显(P>0.05)。结论:急性胰腺炎患者早期外周血中核因子-κB明显激活。可望应用核因子-κB抑制剂抑制核因子-κB激活,控制急性胰腺炎的进展。

Objective To study the relationship between timing and degree of expression of nuclear factor κB activation in acute pancreatitis patients. Methods Forty patients with acute pancreatitis were analyzed. Cytometry was used to detect nuclear factor κB activation in peripheral blood. Results Nuclear factor κB activation was significantly higher at each time point in pancreatitiS patients than that in control group（P〈0.01）. Nuclear factor κB activity increased significantly at 24 hours, and peaked at 24 to 48 hours. Nuclear factor κB activity gradually decreased after 48 hours and was near to the normal level after one week. No statistic difference was found at different time points in control group. Conclusion The activation of nuclear factor κB in peripheral blood is significantly higher at early phrase in acute pancreatitis. Nuclear factor κB inhibitor could be used to prevent the progression of acute pancreatitis.