血管内皮生长因子在鼻息肉组织中的表达和意义

Expression and significance of VEGF in nasal polyps

目的探讨血管内皮生长因子(vascular endothelial growth factor,VEGF)在鼻息肉组织中的表达及其在鼻息肉发病中的意义。方法将鼻息肉患者分为A、B组,A组为Ⅱ型1、2期患者,B组为Ⅱ型3期及Ⅲ型患者。另有20例鼻中隔偏曲患者的正常下鼻甲组织作对照组。采用免疫组化SP法检测三组VEGF的表达。结果正常鼻黏膜中VEGF的染色呈弱阳性,而在A、B组鼻息肉组织中VEGF的阳性率明显高于对照组,B组中阳性率和阳性细胞数均高于A组;VEGF在鼻息肉组织中主要定位于基底膜周围的炎性细胞和上皮细胞以及腺体、血管周围和血管壁内皮细胞。结论VEGF通过在鼻息肉组织中过度表达促进息肉组织内的血管增殖和炎性细胞聚积,促进鼻息肉的发生发展。

Objective To evaluate the role of vascular endothelial growth factor（VEGF） in the pathophysiology of nasal polyps.Methods Forty patients with nasal polyps were divided into two groups： group A（representing type 2 phase 1-2） and group B（representing type 2 phase 3 and type 3）.Also 20 normal inferior turbinate tissues served as the control.The expression of VEGF in three groups was determined by an immunohistochemical method. Results The expression of VEGF was weak in normal nasal mucous but strong in nasal polyps.The expression rate of VEGF in groups A and B was significantly higher than that in the control group,furthermore it was higher in group B than in group A.VEGF is mainly located in the inflammatory cells and epithelial cells surrounding the basilar membrane and inflammatory cells and endothelial cells surrounding the vessels.Conclusion Over-expression of VEGF in nasal polyps may contribute to growth of vessels and accumulation of inflammatory cells,and as a result,enhances development of nasal polyps.