生新复原丸对股骨头无菌坏死患者血液流变学的影响

THE EFFECTS OF SHENGXINFUYUAN PILLS ON BLOOD RHEOLOGICAL INDEXES OF PATIENTS WITH ASEPTIC NECROSIS OF HEAD OF FEMUR

目的探讨生新复原丸对股骨头无菌坏死患者血液流变学的影响及其治疗非创伤性股骨头坏死的作用机制,为临床用药提供理论依据。方法选择股骨头坏死患者68例,采用生新复原丸内服治疗12个月,检测患者治疗前后血液流变学的变化。结果口服生新复原丸药物治疗后,患者血液流变学指标与治疗前相比,Ⅰ、Ⅱ期病人全血粘度及血浆粘度、红细胞聚集指数和刚性指数、血沉方程K值及纤维蛋白原均有所下降(P<0.05),变形指数增高(P<0.05),血球压积无显著性差异(P>0.05)。Ⅲ期及以上患者上述指标虽也有变化但均无显著性差异(P>0.05)。结论生新复原丸可改善股骨头处的血液供应及局部微循环,促进坏死股骨头的修复。

Objective To explore the effects of shengxinfuyuan pills on blood rheological indexes of patients with aspetic necrosis of head of femur. Methods 68 cases were treated with the drug for 12 months and the rheological changes were examined. Results In contrast to the conditions before treatments, the while blood plasma viscosity, erythrocytic aggregation index, the K-value of blood sedimentation equation and the level of fibrinogen all declined to some degree（ P 〈 0.05）, the deformation indexes increased（ P 〈 0.05） and no significant differences occurred in pressure accumulation（ P 〉0.05） when patients in Stage Ⅰ and Stage Ⅱ were examined. No significant changes were discovered in the third stage （ P 〉0.05）. Conclusion Microcirculation can be improved and contribute to the treatment of aspectic necrosis of head of femur when shenxinfuyuan pills are applied.