鼻塞持续呼吸道正压通气治疗新生儿呼吸窘迫综合征的临床观察

NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE VENTILATION IN TREATING NEWBORN RESPIRATORY DISTRESS SYNDROME

目的观察鼻塞持续呼吸道正压通气(NCPAP)治疗新生儿呼吸窘迫综合征(NRDS)的临床疗效。方法将82例NRDS患儿随机分为两组,治疗组41例,在常规治疗的基础上进行NCPAP治疗。对照组41例,仅给予常规抗炎、吸氧、液体疗法等基础治疗。观察比较两组患儿血气指标变化、住院时间、机械通气应用等情况。结果两组治疗后动脉血气pH值、PaCO2、PaO2与治疗前比较均有明显改善(P<0.05或P<0.01)。治疗后治疗组在降低PaCO2和提高PaO2方面显著优于对照组(P<0.05或P<0.01);与对照组相比,治疗组住院时间缩短,机械通气几率降低。结论NCPAP治疗NRDS能更有效地降低PaCO2、提高PaO2,减少有创机械通气的几率,缩短住院时间。

Objective To explore the curative effects of nasal continuous positive airway pressure （NCPAP） ventilation on newborn respiratory distress syndrome（NRDS）. Methods 41 cases of NRDS were treated with NCPAP ventilation along with the routine therapy in the treatment group. Another 41 cases of NRDS were treated with anti-inflammatory therapy, oxygen inhalation and liquid therapy in the contrast group. The blood gas indexes, the hospitalization time, and the application of mechanical ventilation were observed and contrasted. Results The blood gas PH value and the levels of PaCO2 and PaO2 in both groups were greatly improved. Much better effects were got in reducing the levels of PaCO2 and increasing the level of PaO2 in the treatment group. The hospitalization time and the rate of using mechanical ventilation were reduced more significantly in the treatment group than in the contrast group. Conclusion NCPAP ventilation can increase the level of PaO2 and reduce the rate of using traumatic mechanical ventilation and shorten the hospitalization time.