血浆纤维蛋白原水平与复发性流产关系的研究

Study on Association of Plasma Fibrinogen Level with Recurrent Spontaneous Abortion

目的探讨血浆纤维蛋白原与复发性流产的关系。方法应用免疫比浊法检测复发性流产组30例和对照组30例血浆纤维蛋白原(fibrinogen,Fg)的含量。结果复发性流产组血浆Fg水平为(2.31±0.57)g/L,对照组为(3.08±0.57)g/L,差异有统计学意义(p<0.05);2次流产组为(2.59±0.53)g/L,2次以上流产组血浆Fg水平为(1.86±0.24)g/L,差异有统计学意义(p<0.05);早期流产组与晚期流产组血浆Fg水平差异无统计学意义(p>0.05)。结论血浆纤维蛋白原水平降低是复发性流产的发病因素,流产次数是影响纤维蛋白原水平的重要因素,流产时限与血浆纤维蛋白原水平无明显相关。

Objective To investigate the relationship between plasma fibrinogen level and recurrent spontaneous abortion. Method The levels of plasma fibrinogen were determined by turbidimetry in 30 patients with recurrent spontaneous abortion（RSA） and in 30 healthy controls （CON）. Results The plasma fibrinogen level in RSA group was significantly lower than in CON groups （2.31±0.57）g/L vs（3.08±0.57）g/L,（p〈0.05 ）. The plasma fibrinogen level in more than two abortion group was significantly lower than in twice abortion group significantly （2.59±0.53）g/L vs（1.86±0.24）g/L, （p〈0.05） ; No significant difference was found in plasma fibrinogen level between the early abortion group and the later abortion group （p〉0.05）. Conclusion The low level of fibrinogen is a probably risk factor of recurrent spontaneous abortion. The number of abortion is an important factor of fibrinogen levels affect. No close association of plasma fibrinogen level with recurrent spontaneous abortion was found.