补肾健脾汤对绝经后骨质疏松症患者细胞因子、骨密度及雌激素水平的影响

EFFECTS OF TONIFYING KIDNEY AND SPLEEN DECOCTION ON CELLULAR FACTORS,BONE MINERAL DENSITY AND E_2 LEVEL IN POST MENOPAUSAL OSTEOPOROSIS PATIENTS

目的:观察补肾健脾汤对绝经后骨质疏松症(PMOP)患者细胞因子、骨密度及雌激素水平的影响。方法:PMOP患者80例,40例给予降钙素和钙天力治疗,40例在此基础上加用补肾健脾汤,治疗前后进行骨密度测定,并进行组血清E2及细胞因子TNF-α、IL-4、IL-6、IGF-1的测定。结果:补肾健脾汤可明显增强PMOP患者的骨密度,提高雌激素水平,降低血清TNF-α、IL-4及IL-6水平,升高IGF-1水平,作用优于对照组。结论:补肾健脾汤对PMOP有肯定疗效。

Objective: To observe the effects of tonifying kidney and spleen decoction on cellular factors,bone mineral density and E2 level in post menopausal osteoporosis patients. Methods: 80 cases with post menopausal osteoporosis were divided into two groups at random,40 cases were given western medicine,40 cases were given tonifying kidney and spleen decoction based on given western medicine,cellular factors as TNF-α,IL-4,IL-6,IGF-1,bone mineral density and serum E2 were determined before and after treated. Results: Tonifying kidney and spleen decoction could increase BMD of patients with post menopausal osteoporosis,raise their serum E2 level,lower the levels of serum TNF-α,IL-4 and IL-6,increase IGF-1 level,all these effects were better than those in control group. Conclusion: Tonifying kidney and spleen decoction can effectively treat post menopausal osteoporosis.