苯并异噻唑啉酮衍生物的合成及其抑菌性能

Synthesis and antibacterial activity of benzisothiazolone derivatives

以1,2-苯并异噻唑-2(3H)-酮为原料合成了其新的衍生物2-(1,2-苯并异噻唑-2(3H)-酮)-乙酰肼和系列N'-(芳基亚甲基)-2-(1,2-苯并异噻唑-2(3H)-酮)-乙酰肼衍生物,目标化合物的结构经元素分析、IR、UV、1HNMR和质谱确证,并对其波谱性质进行了讨论。测试了苯并异噻唑啉酮化合物对5种水生菌大肠杆菌(Escherichia coli)、金黄色葡萄球菌(Staphyloccus aurueus)、溶藻弧菌(Vibrio alginolyticus)、嗜水气单胞菌(Aeromonas hydrophila)、枯草芽孢杆菌(Bacillus subtilis)的抑制活性。结果表明,此类化合物在100×10-6mol/L下抑菌率均达到90%以上,有良好的抑菌活性。

Novel compounds 2-（3-oxobenzo[d]isothiazol-2（3H）-yl）acetohydrazide and hydrazones of （3-oxobenzo[d]isothiazol-2（3H）-yl）acetohydrazide were synthesized with benzisothiazolone and their structures were conformed by means of UV, IR, MS, elemental analysis and^1H NMR. The antibacterial activity of the compounds was tested on five kinds of bacteria including Escherichia coli, Staphyloccus aurueus, Vibrio alginolyticus, Aeromonas hydrophila, and Bacillus subtilis. The results show that the compounds have a good antibacterial activity and the inhibit efficiency is over 90% in the concentration of 100×10^-6 mol/L.