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环氧化酶和血管内皮生长因子在鼻咽癌中的表达及意义

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摘要 新生血管是肿瘤增生、侵袭和转移的重要环节。血管内皮生长因子(vascular endothelial growth factor,VEGF)是内皮细胞生长促进作用效果最强,特异性最高的因子之一。环氧化酶-2(cyclooxygenase-2,COX-2)是前列腺素生成过程中的重要限速酶。研究表明,COX-2在多种肿瘤中高表达,且可促进肿瘤VEGF表达,它与VEGF共同促进肿瘤新生血管。
出处 《中华放射肿瘤学杂志》 CSCD 北大核心 2008年第3期201-202,共2页 Chinese Journal of Radiation Oncology
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