摘要
目的对比观察肛肠手术后奈福泮和曲马朵患者自控静脉镇痛的效果。方法ASAⅠ~Ⅱ级60例择期骶管阻滞下行肛肠手术的患者,随机分为N组(奈福泮组)30例、T组(曲马朵组)30例,骶管阻滞用药含0.5%罗哌卡因。手术结束时开启静脉自控镇痛泵,N组给奈福泮160 mg+格拉司琼3 mg,T组给曲马朵800mg+格拉司琼3 mg,均稀释至100 ml,背景量2 ml/h,自控剂量0.5 ml/次,锁定时间20 min。术后48h内应用疼痛视觉模拟评分(VAS)对两组患者进行镇痛效果评估,并记录不良反应。结果两组患者的术后疼痛明显减轻(VAS均<3),镇痛效果无统计学差异,N组患者的不良反应明显少于T组。结论奈福泮与曲马朵的肛肠术后镇痛效果相近,但前者不良反应明显少。
Objective To compare the patient controlled intravenous analgesic effect of nefopam and tramadol on postanorectal pain. Methods Sixty patients, ASA I-Ⅱ scheduled caudal block for anorectal surgery, were randomly divided into two groups : Group N ( nefopam group, nefopam 160 mg + gran-isetron 3 mg) 30 cases, group T ( tramadol group, tramadol 800 mg + granisetron 3 mg) 30 cases. 0.5% ropivacaine was used in caudal block. At the end of operation the background infusion of PCA pump was 2 ml/h, a bolus 0.5 ml with 20 minute lock-out. The pain relief of patients in 48 hours, using visual analogue scale (VAS) to assess the analgesic effect of the two groups, were compared. Results The VAS in group N and T patients were significantly reduce postoperatively ( VAS 〈 3 ), and the side effects in group N patients were significantly less than that in group T. Conclusion The analgesic effect of nafopam is similar to tramadol after anorectal operation, but with less side effects.
出处
《实用疼痛学杂志》
2008年第2期110-112,共3页
Pain Clinic Journal
关键词
奈福泮
曲马朵
中医肛肠手术
镇痛
患者控制
Nefopam
Tramadol
Anorectal,Surgery
Analgesia, Patient-Controlled