原发性高血压血压波动性与C反应蛋白的关系

The relation of high sensitive C-reactive protein and blood pressure variability in primary hypertension

目的探讨原发性高血压血压波动性（BPV）与CRP的关系。方法选择64例原发性高血压患者，按有无靶器官损伤（TOD）分为TOD组（34例）和无TOD组（30例），行动态血压监测，以变异系数（CV）作为评价BPV的指标，并与对照组30例进行比较，采用免疫比浊法检测各组hs-CRP水平。同时以平均CV值为界将64例患者分为高CV组和低CV组，比较高CV组、低CV组和对照组hs-CRP水平的变化。结果24h收缩压的CV值及hs-CRP水平在TOD组[（16．12±2．17）％、（7．11±1．04）mg／L]和无TOD组[（13．30±2．64）％、（4．67±1．24）mg／L]与对照组[（10．68±2．19）％、（1．68±1．49）mg／L]比较差异均有统计学意义（P均〈0．05），而且TOD组与无TOD组比较，差异也有统计学意义（P〈0．05）。高CV组（32例）、低CV组（32例）和对照组之间hs-CRP水平也显示了明显的差异。结论炎性反应参与了血压波动，影响疾病的发生与发展。

Objective To explore the relation of high sensitive C-reactive protein （hs-CRP） and blood pressure variability （BPV） in primary hypertension. Methods Sixty-four patients with primary hypertension were divided into target organ damaged （TOD）group and no TOD group. Ambulatory blood pressure monitoring （ABPM） was performed and BPV was assessed by coefficient of variation （CV） . Sixty-four patients were divided into higher CV group and lower CV group. Thirty controls were admitted into control group. The level of hs-CRP was measured. Results The systolic CV and the levels of hs-CRP was significantly different in TOD group [（16.12 ±2.17）%, （7.11 ± 1.04）mg/L]and no TOD group [（13.30 ± 2.64）%, （4.67 ± 1.24）mg/L） ],compared with that in control group [（10.68 ±2.19）%, （1.68 ± 1.49） mg/L]. The levels of hs-CRP were significantly different in higher CV group （n = 32 ）, and lower CV group （n = 32）,compared with that in control group. Conclusion Inflammation may be involved in the occurrence and development of BPV.