TP方案联合热疗治疗非小细胞肺癌的疗效观察

Observational Study on The Effect of Treating Advanced NSCLC Using TP Chemotherapy and Thermotherapy

目的:观察TP方案联合热疗治疗中晚期非小细胞肺癌的疗效。方法:将40例晚期非小细胞肺癌患者随机分为两组,观察组(20例)采用紫杉醇+顺铂(TP方案)化疗联合射频热疗,对照组(20例)仅采用TP方案静脉化疗,21天为一周期,至少完成2周期,评价两组的疗效、生活质量、及不良反应。结果:观察组总有效率60%,对照组总有效率35%,两组有显著性差异(P<0.05);两组患者治疗前后KPS评分的变化有统计学意义;两组毒副反应发生率无显著性差异。结论:TP方案局部热疗联合可提高单纯化疗治疗中晚期非小细胞肺癌的疗效。

Objective： Objective to evaluate the efficacy of TP chemotherapy and thermotherapy as regiment for advanced non- small cell lung cancer （NSCLC）. Methods： Forty NSCLC patients were randomly divided into two groups . Group one （n --20） was treated with paclitaxel plus DDP（TP）chemotherapy combined with thermotherapy . Group two（ n = 20） was treated with regular TP chemotherapy with one cycle of 21 days for two cycles The measures of the efficacy ~ life quality and side effects were compared between the two groups. Resn_lts： The response rate in group one was 60%, and 35% in group two. There was significant difference between the two groups（ P 〈 0.05）. The difference was significant in the change of KPS score before and after treatment between the two groups （P 〈 0.05）. The toxic and side effects of the two groups had no significant difference. Condusion： The use of TP chemotherapy combined with thermotherapy can increase effect in the treatment of advanced NSCLC.