氢化可的松液—液分配平衡预测

Prediction of distribution equilibriumof hydrocortisone in liquid liquid systems

测定了氢化可的松（ＨＣ）的熔点及熔融热，利用ＨＣ在乙酸丁酯、氯仿和去离子水中的溶解度数据预测了不同温度下ＨＣ在乙酸丁酯／水、氯仿／水两体系中的分配系数，并与实验数据进行了比较。结果表明，在考虑了溶剂与水的互溶度之后，运用三元两尾标Ｍａｒｇｕｌｅｓ活度系数表达式对乙酸丁酯／水体系的预测结果比二元两尾标Ｍａｒｇｕｌｅｓ的预测结果有明显改善，与实验结果吻合较好；而三元两尾标Ｍａｒｇｕｌｅｓ式和二元两尾标Ｍａｒｇｕｌｅｓ式对氯仿／水体系的预测结果接近，均与实验结果符合较好。最后讨论了ＨＣ在两相的溶解度之比与ＨＣ在两相的分配系数之间的关系。

Distribution coefficient of hydrocortisone between two liquid phases was predicted by using solubility of hydrocortisone in each phase and other thermodynamics properties of hydrocortisone. It is shown that for system with large miscibility of solvent and water, such as butyl acetate/water system, ternary 2suffix Margules equation can improve the precision in prediction more remarkably than binary 2suffix Margules equation can do. While for chloroform/water system, as miscibility of solvent and water is small, results obtained from ternary 2suffix Margules equation and results from binary 2suffix Margules equation are approaching and coincide with the experimental data. Moreover, relation between the ratio of solubility of hydrocortisone in two phases and distribution coefficient of hydrocortisone was discussed.