高效液相色谱-电喷雾质谱联用研究三氯生的光聚合产物

LC-ESI-MS Study of the Photo-Polymerization Products of Triclosan

三氯生在光解时可能会产生二噁英类物质,因而它在日用化学品中的安全性受到学术界的广泛关注.本文采用高效液相色谱-电喷雾质谱研究了三氯生在紫外光照射下的光聚合反应,通过对产物的准分子离子分析,初步确定了7种光聚合产物.聚合物的分子离子分别为505、540、792,且有同分异构体存在,其异构体个数分别为2个、3个和2个.这些物质的产生主要由三氯生分子间脱除氯化氢、分子上脱除氯离子等过程来聚合完成.在光解溶液中也测到2,8-二氯代二苯并-对-二噁英,该物质则是通过分子自身脱除氯化氢而环化产生.同时应用液相色谱定性分析了不同光源对光聚物产生及含量变化的影响.结果表明,三氯生的光聚合反应受光源的影响显著,UVB比UVA更易产生聚合反应.

The safety of triclosan in the daily-used chemical products has evoked a great deal concern in the academic community due to the possible formation of dioxin in the photo-induced transformation. The photo-polymerization（PPM）of triclosan under UV irradiation and effects of light sources were investigated by using LC-ESI-MS and HPLC. By analyzing the ion chromatogram for different m/z at negative ion mode, three kinds of products （total seven PPM products） with molecular ion 505,540 and 794 respectively were identified. The numbers of their isomers respectively were 2,3 and 2. These compounds were formed by removal of HCI among triclosan molecules or loss of chlo- ride anions. 2,8-dichlorodibenzo-p-dioxin transformed by ring-closure of triclosan was also detected in the photolysed products. The light source effects on the formation of PPM products were also investigated by utilizing the HPLC analysis. It was found that the PPM reaction was strongly affected by the light source, and the UVB was much more effective than the UVA.