肺癌患者血清肿瘤标志物联合检测及临床意义

Detection and Clinical Significance of Combined Measurement of Serum Tumor Markers in Patients with Lung Cancer

目的探讨多种肿瘤标志物蛋白芯片检测系统(C-12)对肺癌的诊断价值,评价在肺癌不同病理类型及分期的表达意义。方法用该检测系统测定120例肺癌患者、100例肺良性病变患者血清中12种肿瘤标志物(AFP,NSE,SF,CEA,CA125,CA153,CA199,CA242,PSA,FPSA,β-HCG及HCG)的水平。结果肺癌组的芯片阳性率显著高于肺良性病变组(73.33%,45.00%),AFP、NSE、SF、CEA、CA125、CA199、CA242血清水平高于肺良性病变组,差别有统计学意义;CEA、CA242阳性率以腺癌组最高,与鳞癌、小细胞肺癌相比差别有统计学意义;肺癌不同分期之间CEA、CA125、CA199、CA242及NSE血清水平存在统计学差异;联合检测较单项检测阳性率提高(73.33%,44.17%)。结论多肿瘤标志物蛋白芯片检测系统在肺良、恶性病变的鉴别诊断中有较高应用价值,同时对于确定肺癌临床分期,鉴别病理类型有一定的意义。

Objective To study the diagnostic values and the clinical significance of multiple tumor marker protein biochip detective system for lung cancer. Methods The serum levels of 12 tumor markers, including AFP, NSE, SF, CEA, CA125, CA153, CA199, CA242, free-PSA ,PSA, β-HCG and HCG ,were measured in 120 lung cancer patients,100 patients with benign pulmonary lesion by the detective system. Results The positive rates of patients with lung cancer were significantly higher than that of patients with benign pul- monary lesion （73.33% ,45.00% ）. The levels of serum AFP, NSE, SF, CEA, CA 125, CA199 and CA242 in lung cancer patients were significantly higher than that in benign pulmonary disease patients and controls （p 〈 0. 05 ） ;CEA and CA242 in adenocarcinoma had the highest positive rate（p 〈 O. 05 ） ;Serum CEA, CA125 ,CA199,CA242 and NSE levels were closely correlated with clinical staging（p 〈 O. 05）. Combined measurement of 12 tumor markers had the higher positive rate than single item measurement（p 〈0.05 ）. Conclu- sion Muhiple tumor marker protein biochip detective system has high reliable practical value in differentiating diagnosis of benign and malignant lung lesion patients, Meanwhile, it is significant for defining clinical stage and identifying pathologic classification as well.