伊曲康唑联合泼尼松治疗儿童脓癣疗效观察

Treatment of Kerion in Children with Itraconazole and Prednisone

目的观察伊曲康唑联合泼尼松治疗儿童脓癣的疗效。方法95例脓癣患儿随机分成两组。治疗组和对照组均给予伊曲康唑100mg/d,晚餐后服用,连续服用4周,治疗组同时联合泼尼松15 mg/d,连用1周(第1周)。结果对照组和治疗组的有效率在治疗结束时分别是47.8%和75.5%,治疗结束后4周的有效率分别是56.5%和79.6%,差异均有统计学意义。结论伊曲康唑联合泼尼松治疗脓癣的疗效优于单用伊曲康唑治疗。

Objective To evaluate the efficacy of itraconazole combined with prednisone in treating kerion in children. Methods 95 cases of children with kerion were divided into two groups randomly. Patients in the treatment group and the control group were given itraconazole 100 mg/day after supper. The therapy continued for 4 weeks. At the same time, patients in the treatment group were given prednisone 15 mg/day for 1 week （the first week）. After the treatment, patients in the two groups were observed for another 4 weeks. Results At the end of treatment, the response rates were 47. 8% and 75.5% respectively. And 4 weeks after the treatment, the re- sponse rates were 56.5% and 79. 6% respectively. There was significant difference between the treatment group and the control group. Conclusion Itraconazole combined with prednisone is more effective than itraconazole in the treatment of children with kerion.