动态观察C反应蛋白在AECOPD的临床意义

The application of the C-reactive protein in the patient with acute exacerbation of the chronic obstructive pulmonary disease(COPD)

目的探讨C反应蛋白(CRP)在慢性阻塞性肺病急性加重期(AECOPD)患者治疗中的临床意义。方法对65例COPD急性加重期患者入院治疗后第2天及感染控制后采血,测定CRP、白细胞计数,中性粒细胞百分比,血沉,同时观察患者体温,并进行比较。结果COPD急性加重期患者在感染期CRP浓度显著高于感染控制后(P<0.01),且CRP的阳性率明显高于白细胞计数,中性粒细胞百分比,血沉,体温。结论CRP有助于COPD急性加重期的早期发现,并可作为判断疗效的指标之一。

Objective To study the diagnosis and treatment using C-reactive protein （CRP） of acute exacerbation of the chronic obstructive pulmonary disease （COPD）. Method CRP, WBC, positive rate of neutrophil, ESR and body temperature were measured in 65 COPD patients when they had just had clinic visit, and were compared to the measures after the treatment with effective antibiotics. Resuits Levels of serum CRP was obviously higher before than after the treatment with effective antibiotics（P〈0.01）. The positive rate of CRP was higher than WBC,so were the positive rate of neutrophil, ESR and body temperature. Conclusion CRP is a good indicator in early diagnosis of acute exacerbation of COPD and also a guide to evaluate the therapeutic effects.