二巯基丙磺酸钠治疗急性毒鼠强中毒实验研究

Sodium dimercaptopropanesulfonate for treatment of acute tetramine intoxication

目的探讨二巯基丙磺酸钠(Na-DMPS)在急性毒鼠强中毒治疗中的解毒疗效。方法将30只小鼠分为两组(每组15只),用一次性口服毒鼠强染毒小鼠建立动物实验模型,并给予对照组生理盐水和Na-DMPS组腹腔注射(每10 g体重注射2.5 mg),观察各组小鼠中毒惊厥潜伏期、1小时内抽搐间隔时间、死亡小鼠数、平均死亡时间和病死率等指标。结果Na-DMPS组惊厥潜伏期、平均死亡时间和24小时病死率与对照组比较,差异无显著性意义(P>0.05)。结论二巯基丙磺酸钠在急性毒鼠强中毒中无肯定的治疗作用。

Objective To verify the therapeutic effect of Sodium dimercaptopropanesulfonate （ Na-DMPS） on acute tetramine poisoning. Methods Thirty mice were divided into two groups randomly and equally （ control group and Na-DMPS group）. The animal models were made by orally given tetramine. The results including the time of convulsion and death, the number of died mice and the mortality were recorded immediately after injecting Na-DMPS intraperitoneally in the test group and normal saline in the control group, Results There were no significant differences in the incubation period of convulsion, average death time, and 24 h mortality between Na-DMPS group and control group （ P 〉 0. 05 ）. Conclusion The antidotal effect of Na-DMPS on acute tetramine poisoning is not verified.