抑郁症的神经可塑性机制

Neural plasticity mechanism of depression

以抗抑郁症药物的作用机制反推抑郁症的发病机制存在局限性,而且两者至今并不完全清楚。最近的证据显示基因和早期生活应激事件与抑郁症的发生存在密切关系,最终与神经可塑性的细胞分子机制汇聚。展现了对抑郁症的发生机制和抗抑郁症药物的作用机制的最新理解。

The current hypothesis of depression is limited by back reasoning from the action of antidepressant, because both the pharmacological and pathological mechanisms are not fully understood. Recent evidence shows that genes and early life stress are associated with depression, and the mechanisms are converged on those of neural plasticity. These developments open a new avenue to understand the pathological and pharmacological mechanisms of depression.