摘要
目的探讨幽门螺杆菌(HP)感染及其在冠心病(CHD)发病中的作用。方法对CHD组(73例)[包括急性冠脉综合征(ACS)患者(A组,31例)和症状稳定者(B组42例)]和非CHD患者(C组26例)用酶联免疫吸附法(ELISA)测定血清HP-IgG、IgM,用放射免疫法检测血清白介素-6(IL-6)和内皮素(ET)。结果①CHD组HP-IgG、IgM阳性率与非CHD组间差异有统计学意义(P<0.05),特别是A组与C组间差异有统计学意义(P<0.01)。②IL-6在B组与C组间差异无统计学意义,但A组明显高于B组及C组,差异有统计学意义(P<0.01)。CHD组特别是A组ET水平明显高于C组(分别P<0.05及0.01)。③IgM阳性率太低与IL-6、ET的相关性无法统计。IgG阳性率与ET值呈低度相关(r=0.326,P<0.05);与IL-6值具有显著相关性(r=0.685,P<0.05)。结论HP感染与CHD发病有关,HP感染可能通过IL-6、ET升高在CHD特别是ACS的发生和发展中起重要作用。
Objective To study the relation Helicobacter pylori between (HP} infection and coronary artery heart disease (CHD) and its possible role in CHD and ACS. Methods Enzyme-linked immunosorbent assay was used to measure the plasma HP-IgM, IgG and radio-immunoassay was used to measure the plasma IL-6, ET in 73 patients with CHD (CHD group) and 26 patients without CHD (non-CHD group). The CHD group was divided into acute coronary syndrome group (group A,n=42) and stable symptom group (group B,n=31 ). Results (1)The positive rate of HP-Ig-M, IgG was higher in CHD group (especially in group A) than that in non-CHD group (P〈0.05, P〈0.01 separately). (2)The plasma levels of IL-6 were the same in group B and control group, but the plasma level was higher in group A than that in group B and control group (P〈0.01). The plasma level of ET in CHD group, especially in group A was higher than that in control group (P〈O.O5,P〈O.O1 separately). (3) The positive rate of HP-IgM was too low to be statistical,but IgG was low correlated with ET (r=0.326,P〈 0.05), was smartly correlated with IL-6 (r=O.685,P〈O.05). Conclusion HP infection was related to CHD and ACS. HP infection may play an important role in the process of CHD, esoeciallv in ACS.
出处
《中国心血管病研究》
CAS
2008年第5期368-370,共3页
Chinese Journal of Cardiovascular Research