幽门螺杆菌感染及其在冠心病发病中的作用

Helicobacter pylori infection and its possible role in coronary artery heart disease

目的探讨幽门螺杆菌(HP)感染及其在冠心病(CHD)发病中的作用。方法对CHD组(73例)[包括急性冠脉综合征(ACS)患者(A组,31例)和症状稳定者(B组42例)]和非CHD患者(C组26例)用酶联免疫吸附法(ELISA)测定血清HP-IgG、IgM,用放射免疫法检测血清白介素-6(IL-6)和内皮素(ET)。结果①CHD组HP-IgG、IgM阳性率与非CHD组间差异有统计学意义(P<0.05),特别是A组与C组间差异有统计学意义(P<0.01)。②IL-6在B组与C组间差异无统计学意义,但A组明显高于B组及C组,差异有统计学意义(P<0.01)。CHD组特别是A组ET水平明显高于C组(分别P<0.05及0.01)。③IgM阳性率太低与IL-6、ET的相关性无法统计。IgG阳性率与ET值呈低度相关(r=0.326,P<0.05);与IL-6值具有显著相关性(r=0.685,P<0.05)。结论HP感染与CHD发病有关,HP感染可能通过IL-6、ET升高在CHD特别是ACS的发生和发展中起重要作用。

Objective To study the relation Helicobacter pylori between （HP} infection and coronary artery heart disease （CHD） and its possible role in CHD and ACS. Methods Enzyme-linked immunosorbent assay was used to measure the plasma HP-IgM, IgG and radio-immunoassay was used to measure the plasma IL-6, ET in 73 patients with CHD （CHD group） and 26 patients without CHD （non-CHD group）. The CHD group was divided into acute coronary syndrome group （group A,n=42） and stable symptom group （group B,n=31 ）. Results （1）The positive rate of HP-Ig-M, IgG was higher in CHD group （especially in group A） than that in non-CHD group （P〈0.05, P〈0.01 separately）. （2）The plasma levels of IL-6 were the same in group B and control group, but the plasma level was higher in group A than that in group B and control group （P〈0.01）. The plasma level of ET in CHD group, especially in group A was higher than that in control group （P〈O.O5,P〈O.O1 separately）. （3） The positive rate of HP-IgM was too low to be statistical,but IgG was low correlated with ET （r=0.326,P〈 0.05）, was smartly correlated with IL-6 （r=O.685,P〈O.05）. Conclusion HP infection was related to CHD and ACS. HP infection may play an important role in the process of CHD, esoeciallv in ACS.