幽门螺杆菌感染与血清抗体及滴度的相关性研究

Analysis of Correlation between Helicobacter Pylori Infection and Serum Antibody Titer

为了解幽门螺杆菌（ＨｅｌｉｃｏｂａｃｔｅｒＰｙｌｏｒｉ，ＨＰ）感染时机体的免疫状况，我们对１３４例上消化道疾病患者的血清免疫球蛋白进行了检测。结果表明，细菌培养阳性患者的三种血清抗体滴度显著高于细菌培养阴性患者。血清ＩｇＧ、ＩｇＡ、ＩｇＭ阳性与细菌培养阳性的符合率分别为７９．１％，７４．６％和４３．２％。活动性胃炎和非活动性胃炎的细菌培养阳性率分别为６６％和４２％。证实ＨＰ菌感染与活动性胃炎的发生密切相关，而与胃炎的严重程度无显著性差异。并证实了抗ＨＰ菌ＩｇＧ、ＩｇＡ检测具有较高的诊断ＨＰ菌感染的敏感性和特异性。

134 patients suffered from upper gastrointestinal infections or diseases were detected by immunoglobulin IgG,IgA,IgM for understanding the immunological situation in Helicobacter pylori(HP) infection.The titers of three antibody in positive patients of bacterial culture were significantly higher than negative patients.The correspondence between positive rates of IgG,IgA and bacterial culture was 79.1% and 74.6% respectively.The positive rates of bacterial culture in active and inactive gastritis was 66% and 42.2%.The correlation between HP infection and active gastritis was proved.There were no significant differences with serious degree of gastritis.The detection of antiHP IgG and IgA was proved to be sensitive and specific in HP infection diagnosis