初诊2型糖尿病患者早期胰岛素强化治疗评价

Early Intensive Insulin Treatment and Evaluation in Newly Diagnosed Type 2 Diabetic Patients

目的评价初诊2型糖尿病患者早期胰岛素强化治疗的效果。方法对26例初诊2型糖尿病患者进行早期胰岛素强化治疗。结果空腹血糖(FPG),餐后2h血糖(2hPG),糖化血红蛋白(HbA1C)水平均显著下降(P<0.01),而空腹C肽水平增高(P<0.05),餐后2hC肽水平(2hCP)明显升高(P<0.01)。结论早期胰岛素强化治疗能尽快解除高糖毒性,显著恢复胰岛β-细胞功能,减轻胰岛素抵抗。

Objective To evaluate the effect of early intensive insulin treatment in newly diagnosed type 2 diabetic patients. Methods Early intensive insulin treatment was performed in 26 newly diagnosed type 2 diabetic patients. Results The levels of fasting plasma glucose （FPG） ,2 - hour plasma glucose （2hPG） and hemoglobin （HbA1 C ） all decreased significantly （ P 〈 0. 01 ）, whereas the level of fasting C -peptide was increased;The level of 2 -hour C -peptide（2hCP） increased significantly. Conclusion Early intensive insulin treatment could rescind high glucose toxicity as soon as possible,recover significantly islet β -cell function and reduce insulin resistance.