摘要
本文以非甾体抗炎药吲哚美辛为模型药物制备了骨架型缓释片剂,以体外溶出为检验指标,考察了甲壳胺的脱乙酰度、表观粘度及用量对药物释放的影响,并确定了甲壳胺的脱乙酰度及粘度范围。实验结果表明,缓释作用随脱乙酰度升高而降低;随用量增多而增强;粘度对药物释放的影响随脱乙酰度不同而不同。脱乙酰度为85％的甲壳胺,其缓释作用随表观粘度的增大而增大;脱乙酰度为75％的甲壳胺缓释作用随粘度升高而降低。
The suitability of chitosan for use as vehicles for the sustained release of drugs was examined. Indomethacin was chosen as a model drug in this study. The effects of different deacetylation degree and apparant viscosity and concentration of chitosan on drug release profiles were studied. The results revealed that as the deacetylation degree increased the release rate increased,as the concentration of chitosan increased the release rate decreased. The effects of apparant viscosity of chitosan on the drug release were different in different deacetylation degree.
出处
《天然产物研究与开发》
CAS
CSCD
1997年第4期68-71,共4页
Natural Product Research and Development
关键词
甲壳胺
缓释骨架片剂
药物辅料
chitosan
hydrophilic matrix tablet
sustained-release
