SCID小鼠原位移植建立人胃癌高转移模型

Metastatic Models of Human Gastric Carcinoma Established by Orthotopic Implantation of Histologically Intact Specimens in SCID Mice

为建立人胃癌高转移模型，用人胃癌组织块ＳＧＣ－７９０１原位移植于ＳＣＩＤ小鼠，第４周末移植瘤向淋巴结和肝脏等器官转移，转移率达６６．７％（２／３），第６周末转移率高达１００％（１０／１０）。结果提示，ＳＣＩＤ小鼠原位移植人胃癌组织块后短期内即可发生胃癌转移，且转移率高。

To establish the metastatic model of human gastric carcinoma,the histologically intact gastric adenocarcinoma specimens were implanted in the gastric walls of SCID mice.The results showed that the metastasis to the lymph nodes (10/10),livers (8/10) and lungs (4/10) occured 6 weeks after the implantation.These revealed that the orthotopic implantation of histologically intact carcinoma in SCID mice could give rise to high metastatic rate in short duration.