摘要
给大鼠口服甲状腺片，平均每只４ｍｇ／ｄ，连续６０ｄ，然后取血测三碘甲腺原氨酸（Ｔ３）和甲状腺素（Ｔ４）浓度，并观察心肌病理学改变。结果：实验组大鼠出现甲亢体征，Ｔ３、Ｔ４分别为０．８１±０．１１和３４．７０±０．９１ｎｍｏｌ／Ｌ，均高于对照组（Ｐ＜０．０５）；光镜下，见心肌纤维排列紊乱，横纹不清，纵纹断裂，淋巴细胞浸润，并见灶状纤维化和灶状脂肪变性；电镜下，见大部分肌原纤维断裂，肌浆内线粒体肿大。
The high serum levels of thyroid hormones in rats were induced by oral administration of thyroid tablets (average dose for each rat:4mg/d×60d).The serum levels of T 3 and T 4 of the rats were measured,and the myocardial histopathological changes were observed. The results showed that at the end of the administration the serum levels of T 3,T 4 were 0.81±0.11,34.70±0.91 nmol/L respectively,and were higher than those in control animals.Under optic microscope the myocardial fibers were found to be disorder in pattern with vague cross striations and broken longitudinal striations.Fibrosis,fatty degeneration and lymphocyte infiltration were found in the pathological foci.Under electron microscope,most of the myofibrils were found to be broken,the Zlines disappeared or fused with each other,and the mitochondrias in the myocytes were swelled.
出处
《上海实验动物科学》
1997年第4期220-222,共3页
Shanghai Laboratory Animal Science
