不同分子量透明质酸治疗兔膝骨关节炎疗效观察

Observe and analysis the efficacy in the treatment of rabbit knee osteoarthritis with different molecular weight hyaluronic acid

目的观察不同分子量透明质酸Hyalgan与Synvisc对兔膝骨关节炎的疗效并作出作出评价。方法将18只实验兔以单侧前交叉韧带切断术制作兔膝骨关节炎模型,术后2周随机分成Hyalgan治疗组(A组)、Synvisc治疗组(B组)、对照组(C组)。A组予Hyalgan0.2ml,B组予Synvisc0.2ml,C组予0.9%氯化钠注射液0.2ml,均行关节腔内注射,每周1次,连续4周。术后10周处死3组动物,取关节软骨行大体观察和显微镜下组织学观察,Mankin法评分。结果兔膝关节软骨损伤程度A组和B组均明显轻于C组(P<0.05),而B组又明显轻于A组(P<0.05)。结论分子量较大的透明质酸制剂Synvisc对兔膝骨关节炎近期治疗效果优于Hyalgan。

Objective To observe and analysis the efficacy with different molecular weight hyaluronic acid（hyalgan and synvisc）in the treatment of rabbit knee osteoarthritis. Methods To establish eighting rabbit knee osteoarthritis model by the method of ACLT. Two weeks after operation,all animails were randomly divided into three groups （6 rabbits per group）. （A）treated with hyalgan injecting in the joint cavity,once each week, continuously 4 weeks.（B） treated with synvisc as B group. （C） treated with NS .Ten weeks after operation,all animails were killed. Took the articular cartilage in right thigh bone condyle to observe with eyes and light microscope. Then scored according to the method of Mankin. Results The knee articular cartilage damage in rabbit which treated with hyalgan or synvisc is smaller than non-treated （P〈0.05）. Damage in rabbit which treated with synvisc is smaller than which treated with hyalgan （P〈0.05）. Conclusion The near future efficacy of bigger molecular weight hyaluronic acid synvisc in the treatment of rabbit knee osteoarthritis supass the hyalgan.