脑血管血流动力学积分变化与卒中风险的关系

Relationhip Between the Change of Accumulative Scores of Cerebrovascular Hemodynamics and the Risk of Stroke

目的：比较不同人群脑血管血流动力学参数（CVHP）综合积分，分析积分变化与卒中风险的关系。方法：在整群抽取的社区自然人群中选择10565名年龄≥40岁的人群，进行危险因素调查和CVHP检测，以统一的方法对CVHP进行积分，随访卒中发病情况。将研究对象分为正常人、单个危险因素暴露、多个危险因素暴露、随访中新发卒中组，按年龄、性别分组，分别比较各组人群CVHP积分的差异和变化规律。结果：从正常人到新发卒中组4组人群中，男性CVHP积分分别为86．44±20．69、72．07±28．10、60．82±34．64和42．01±29．36，女性分别为83．95±22．19、67．97±29．73、59．91±31．34和42．64±28．00，呈逐渐降低趋势。同一年龄层上述4组人群CVHP积分及其分布均有显著差异（P〈0．01）。同一因素各年龄组问CVHP积分及其分布也有显著差异（P〈0．01）。结论：从正常人、危险因素暴露到卒中前的高危状态，CVHP积分呈逐渐降低的变化规律，积分降低与卒中风险上升密切相关，可作为卒中预测指标。

Objective： To compare the accumulative scores of cerebrovascular hemodynamic parameters （CVHP） in different populations and to analyze the relationship between the change of accumulative scores and the risk of stroke. Methods： A total of 10 565 participants aged 40 years and above were selected from a cluster sampling community-based population, Their risk factors were investigated and CVHP was evaluated, The CVHP scores were accumulated by a unified approach, and the incidence of stroke was followed up. The participants were grouped into health adult, single factor exposure, multiple-factor exposure, and newly developed stroke during the follow-up period, The differences of CVHP accumulative scores and the change law among the 4 groups were compared respectively according to age and sex. Results： The accumulative scores of the mean （SD） CVHP in the health adult, single factor exposure, multiple-factor exposure, and newly developed stroke groups were 86.44 （20.69）, 72.07 （28.10）, 60. 82 （34.64）, and4.01 （29.36） in men respectively, and they were 83.95 （22.19）, 67.97 （29.73）, 59.91 （31.34）, and 42.64 （28.00） in women respectively, which had a tendency to gradually decrease, The accumulative scores of CWHP and their distributions at the same age stage in all the 4 groups had significant differences （P 〈0.01 ）. The accumulative scores of CVHP and their distributions for the same factors between all age groups also had significant differences （P 〈 0.01）. Conclusions：The accumulative scores of CVHP had a tendency to gradually decrease from the health adults, risk factor exposure to high risk status before stroke, The decrease of the acctumulative scores is closely associated with the increase of stroke risk, which can be used as a predictor of stroke.