摘要
髓鞘相关抑制因子是中枢神经系统轴突再生的主要障碍，其中Nogo—A是少突胶质细胞合成的一种重要抑制因子。在缺血性脑血管病动物模型中，Nogo—A的表达水平发生明显变化；针对Nogo—A及其下游通路的治疗措施，能有效促进轴突再生和改善神经结构可塑性，促进功能恢复，为人类脑血管病治疗模式的发展提供可靠的理论基础。
Myelin-associated inhibitory factor is a major obstacle for axonal regeneration in the central nervous system, and Nogo-A is an important inhibiting factor synthesized by oligodendrocytes, The expression levels of Nogo-A changed significantly in a model of ischemic cerebrovascular disease; the therapeutic measures aiming at Nogo-A and its downstream pathway can effectively enhance axonal regeneration, improve the plasticity of neural structure, and promote functional recovery, qlais provides a reliable theoretical basis for the development of therapeutic mode in human cerebrovascular diseases.
出处
《国际脑血管病杂志》
2008年第4期313-316,共4页
International Journal of Cerebrovascular Diseases
