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Visfatin与糖脂代谢的关系 被引量：2

Relationship between Visfatin and Glycolipin Metabolism
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摘要 Visfatin是新发现的由内脏脂肪细胞高表达的一种脂肪细胞因子,其具有类胰岛素作用,从而降低血糖;还能够促进脂肪组织的分化、合成及积聚。而对于visfatin与胰岛素抵抗之间的关系目前仍不清楚。现有研究表明,visfatin可能是联系糖脂代谢之间的未知环节,它的发现为研究肥胖和糖尿病的发病机制增加了新内容,可能为糖尿病治疗提供一个新的靶点。 Visfatin （pre-B-cell colony-enhancing tactor,PBEF） is a newly iound novel adipokine having high expression in adipocvte. It not only can decrease blood sugar because of its insulin-like effect, but also can promote the differentiation, svnthesis and accumulation of fatty tissue. Now, the relationship between Vis- fatin and insulin resistance is not very clear. The recent researches showed that visfatin may be the unknown link connecting glocuse metabolism and lipid metabolism. The finding of vistatin will provide new idea in studying the mechanism of obesity and diabetes, which will provide new target for the diabetic therapy.
作者 阮希成 刘礼斌
机构地区 福建医科大学协和临床医学院内分泌科
出处 《医学综述》 2008年第10期1540-1542,共3页 Medical Recapitulate
关键词 内脂素 糖脂代谢 肥胖 糖尿瘸 胰岛素抵抗 Visfatin Glycolipin metabolism Obesity Diabetes Insulin resistance
分类号 R587 [医药卫生—内分泌] R589.1 [医药卫生—内分泌]
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参考文献17

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同被引文献23

  • 1郁琦.多囊卵巢综合征诊治标准专家共识[J].中国实用妇科与产科杂志,2007,23(6):474-474. 被引量：107
  • 2Fukuhara A,Matsuda M,Nishizawa M,et al.Visfatin:a protein secreted by visceral fat that mimics the effects of irsulin[J].Science,2005,307 (5708):426-430.
  • 3Matsuzawa Y.Therapy Insight:edipoeytokines in metabolic syndrome and related cardiovascular disease[J].Nat Clin Pract Cardiovase Med,2006,3(1):35-42.
  • 4Sandeep S,Velmumgan K,Deepa R,et al.Serum visfatin in relation to visceral fat,obesity,and type 2 diabetes mellitus in Asian Indians[J].Metabolism,2007,56(4):565-570.
  • 5Tan BK,Chen J,Digby JE,et al.Increased Visfatin mRNA and Protein Levels in Adipose Tissue and Adipocytes in Women with Polyeystie Ovary Syndrome:Parallel Increase in Plasma Visfatin[J].J Clin Endocrin Metab,2006,91(12):5022-5028.
  • 6Chan TF,Chen YL,Chen HH,et al.Increased plasma visfatin concentration in women with polycystic ovary syndrome[J].Fertil Steril,2007,88(2):401-405.
  • 7Kowalska I,Straczkowski M,Nikolajuk A,et al.Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome[J].Hum Repred,2007,22(7):1824-1829.
  • 8Berndt J,Klating N,Kralisch S,et al.Plasma vlsfatin concentrations and fat depot-specific mRNA expression in humans[J].Diabetes,2005,54(10):2911-2916.
  • 9曹泽毅．中华妇产科学[M]．北京：人民卫生出版社，2005：2814．
  • 10Antuna -Puente B, Feve B, Fellabi S, et al. Adipokines , The missing link between insulin resistance and obesity[J]. Diabetes & Metabolism, 2008, 34(8): 2-11.

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医学综述
2008年 第10期

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