摘要
腺苷酸活化蛋白激酶(AMPK)是一种重要的蛋白激酶,作为机体能量监测器,其活性受腺苷酸活化蛋白/三磷酸腺苷比例调控。AMPK被运动、二甲双胍及噻唑烷二酮类激活后,可增加骨骼肌对葡萄糖的摄取、增强胰岛素敏感性、增加脂肪酸氧化,从而改善胰岛素抵抗。AMPK不仅可在细胞水平作为能量的感受器,还可以通过激素和细胞因子,如瘦素、脂联素来参与调节机体的能量消耗和能量摄入。AMPK为治疗胰岛素抵抗提供了新的药理靶点。文章仅就AMPK介导运动、二甲双胍、噻唑烷二酮类、瘦素和脂联素等对胰岛素抵抗的改善简要概述。
AMP-activated protein kinase （AMPK） is an important protein kinase. Its activity is controlled by ratio of. AMP/ATP as an energy monitor of the body. AMPK can be activiated by movement, met-formin and thiazolidinediones,which will then can increase glucose intake of skeletal muscle,improve insulin sensitivity and fatty acid oxidation and at last,can ameliorate insulin resistance. AMPK not only can be considered as energy susceptor in cell level, but also can regulate the energy consumption and energy intake by some hormones and cytokines, such as leptin and adiponctin. AMPK provide new pharmacal target for the therapy for insulin resistance. This article reviews the improvement of insulin rresistance mediated by AMPK resulting from motion .mefformin .thiazohdinediones .leptin and adiponectin.
出处
《医学综述》
2008年第10期1543-1545,共3页
Medical Recapitulate
