摘要
霍乱是一种烈性肠道传染病,是我国传染病防治法规定的甲类传染病。国内外不少学者发现,菌毛与霍乱弧菌的黏附定居有关,其中甘露糖敏感血凝素(MSHA)属于Ⅳ型菌毛,决定Ⅳ型菌毛的血凝活性。MSHA为一免疫原,同时在霍乱弧菌在环境中存活方面起着特殊作用。主要由霍乱弧菌ElTor生物型和O139产生,古典生物型存在其结构基因mshA,但仅以极低水平表达并不产生MSHA。MSHA在霍乱弧菌疫苗及相关诊断试剂盒的研制方面有一定的实用价值。
As a severe enteric contagious disease, Cholera is a class A contagious disease on the Law of the People＇s Republic of China on the Prevention and Treatment of Communicable Diseases. Researchers have found that pilus is related to the adhesion and colonization of V. cholerae.. Mannose-Sensitive Hemag-glatinin （MSHA） belongs to the members of type IV pilas,which can determine its activity of hemagglatination.. MSHA is a kind of immunogen,and plays a special role in survival of V. cholerae in the environment. MSHA is mainly produced by E1 Tor biotype and V. cholerae O139. Classical biotype vibrios also has structral gene, mshA, but it can no t produce MSHA because of gene expression in the very low level. MSHA has some what practical value in the vaacine study of Vibrio cholerae and related diagnostic kit.
出处
《医学综述》
2008年第10期1563-1565,共3页
Medical Recapitulate
