氯诺昔康超前镇痛用于无痛人工流产的临床观察

The Preemptive Application of Lornoxicam in Painless Induced Abortion

目的观察氯诺昔康超前镇痛应用于无痛人工流产手术的效果。方法60例自愿实施全身麻醉的人工流产手术的门诊患者随机分为2组，氯诺昔康复合异丙酚组（简称LP组）和异丙酚鞋（简称P组），每组30例。LP组在静注异丙酚之前5～8min先静注氯诺昔康8mg，术中使用异丙酚麻醉；P组无术前用药，术中用药同LP组，2组患者异丙酚的诱导剂量均为2mg／kg，术中根据患者创躯体反应必要时追加异丙酚1／3-1／2诱导量。记录诱导前后的血压、心率、异丙酚用量、术中肢刊情况、追加用药的量及例数、清醒时间及术后患者下腹疼痛的视觉模拟疼痛评分。结果注药后：min的血压变化2组比较无显著性差异（P〉0．05）；2组异丙酚用量、术中肢动情况、清醒时间、追办用药的量及例数有显著性差异（P〈0．05），LP组患者术后清醒和定向力恢复迅速，下腹疼痛程度轻于P组，术后5～10min的疼痛评分2组比较有显著性差异（P〈0．05）。结论氯诺昔康超前镇痛应用于无痛人工流产手术，可减少异丙酚用量，缩短术后清醒时间，使循环更趋平稳，对患者术后的下腹疼痛有明显镇痛作用。

Objective To evaluate the preemptive application effect of Lomoxicam during painless induced abortion. Methods 60 female patients undergoing painless abortion were randomized two groups：Lor-noxicam plus propofol （group LP, n = 30 ） and propofol alone（ group P, n = 30）. Patients in group LP received lomoxicam 8mg at 5 -8min before operation. All the patients were given propofol 2mg/kg to induce general anesthesia, additional dosage of propofol were given 1/3 - 1/2 of induced dosage according to the condition during operation. The total dosage of propofol, perceptive time,The blood pressure, heart rate and SPO2 were measured at preoperative and intraoperation. The total dosage of propofol, perceptive time, the movement nausea and vomiting were recorded, pain intensity of lower abdom final was assessed using the VAS score. Results There was no significant difference in blood pressure after injection in 2min compared with two groups. There was significant difference in the total dosage of propofol, the movement during operation, the perceptive time, additional dosage of propofol and cases （P〈 0.05 ）. The group LP showed a significant decrease in the total dosage of propofol and less pain intensity of lower abdomen final by VAS compared with group P（P 〈0.05 ）. Conclusion Lomoxicam plus propofol used in painless induced abortion can significantly decrease the total dosage of propofol and the pain intensity of lower abdomen final after operation.