落新妇甙对大鼠肺移植排斥反应的抑制作用

Suppression of Lung Allograft Rejection in Rats by Astilbin

目的:探讨落新妇甙对大鼠肺移植排斥反应的抑制作用。方法:采用大鼠左侧单肺移植模型。随机将肺移植后的40只大鼠分为4组:A组肺移植后用生理盐水(1ml/天)灌胃,B组肺移植后用环孢素A(5mg/kg/天)灌胃,C组肺移植后用落新妇甙(1ml/kg/天)灌胃,D组肺移植后用环孢素A(2.5mg/kg/天)及落新妇甙(1ml/kg/天)灌胃。术后第10天切取移植肺观察肺急性排斥反应分级情况。结果:B组、C组及D组移植肺排斥反应分级均低于A组(P<0.05～0.01);D组移植肺急性排斥反应最轻,优于C组(P<0.05)和B组(P<0.01)。结论:落新妇甙对肺移植排斥反应有较强的抑制作用,并与环孢素A有协同作用。

Objective:To study the suppression effect of Astilbin on lung allograft rejection in rats.Method:The model of rat left lung transplantation was set up.Forty lung transplanted rats were divided in to four groups randomly:group A were fed with normal saline 1 ml per day,group B were fed with CsA 5mg/kg per day,group C were fed with Astilbin 1mg/kg per day,and group D were fed with Astilbin 1 ml/kg per day and CsA 2.5mg/kg per day.Histopathological rejection grade of the lung graft were analyzed after 10 days.Results:In group B,C and D,the histopathological rejection grade of the lung graft was significantly lower as compared with group A.The histopathological rejection grad of the grafts in group D was significantly lower as compared with group C(P<0.05)and group B(P<0.01).Conclusion:Astilbin can suppress lung allograft rejection and has synergistic reaction with CsA.