角膜上皮移植对角膜碱烧伤表层新生血管抑制的实验研究

Inhibition the corneal superficial neovascularization by keratoepithelioplasty after alkali burn in rats

为评价角膜上皮移植术对角膜碱烧伤后表层新生血管的抑制作用，对大鼠角膜全周碱烧伤后立即行上缘自体角膜上皮移植术，连续观察５周。结果，６４％移植区角膜表面无或有很少新生血管，组织学证实为角膜上皮表型。而９５％的对照组角膜表面全部新生血管化，组织学显示有散在杯细胞为结膜上皮。本文提示角膜上皮移植术对碱烧伤后重建角膜表面的完整性，并预防角膜新生血管化，具有重要价值。

o evaluate the role of keratoepithelioplasty(KEP)for inhibition the corneal superficial neovascularization after alkali burn.Experimental eyes were injured at the circumferential limbal zones by alkali.KEP was performed on the upper limbus with autogeneous lenticules immediately.Examination was taken up to 5 weeks.Results:64% of the transplantative area of the corneas were no or much less new vessels,and the regenerated epithelium was proved histologically to be corneal epithelial phenotype.While,95% of the corneas in controls were neovascularization.The epithelium of them were conjunctival epithelium,some goblet cells were seen in it.Conclusion:This study suggested that KEP played a important role in blocking the ocular surface neovascularization and reconstructing the corneal epithelial integrity after alkali burn.