AOAb与卵巢反应性的相关性

The relative relationship of anti-ovarian antibody and the responsivity of ovarian.

目的:探讨抗卵巢抗体(AOAb)对卵巢反应性的影响。方法:选择在本生殖医学中心进行IVF-ET技术治疗的血清AOAb阳性妇女35例(研究组)、血清AOAb阴性妇女198例(对照组)作为研究对象,观察两组妇女卵巢体积、基础FSH、基础卵泡数、IVF-ET周期获卵子数等指标,同时根据获得卵子数分组,分析其与bFSH、Gn用量的相关性。结果:两组患者卵巢大小无明显区别,但是研究组bFSH水平明显高于对照组,基础窦卵泡数明显低于对照组;研究组Gn用量显著高于对照组,而获卵子数少于对照组;获卵子数与Gn用量及基础FSH呈负相关。结论:AOAb阳性IVF-ET妇女卵巢储备功能已经开始下降,常规对IVF-ET妇女进行血清抗卵巢抗体检测是必要的。

Objective： To investigate the effect of anti - ovarian antibody （AOAb） on the responsivity of ovarian. Methods： 35 women with positive AOAb in serum and 198 women with negative AOAb in serum were comprised the study group and control group, respectively. The size of ovarian, base FSH, the number of antral and recovered oocyte in IVF - ET cycle were observed. The ovarian responsivity between the two groups were compared, and the relationship between it and bFSH, dose of Gn was analyzed. Results： There was no significant difference in size of ovarian, but the bFSH was higher in study group and the antral oocyte was less than control group; Although the more dose of Gn was used but less oocytes were recovered; There had a negative relative relationship between bFSH, dose of Gn and number of recovered oocyte. Conclusion： The ovarian＇s reserve capability has decreased in that women with positive AOAb, it is necessary to detect the AOAb as a regular test before the therapy of IVF - ET.