慢性常压低氧高二氧化碳肺动脉高压大鼠血浆内皮素变化及意义

CHANGES OF PLASMA ENDOTHELIN AND ITS SIGNIFICANCE IN RATS WITH PULMONARY HYPERTENSION INDUCED BY CHRONIC NORMOBARIC HYPOXIA AND HYPERCAPINIA

应用低Ｏ２高ＣＯ２肺动脉高压大鼠模型，观察了不同低Ｏ２高ＣＯ２时间血浆内皮素含量（ＥＴ）、平均肺动脉压（ｍＰＡＰ）、右心室重量（ＲＶ／１００ｇＢＷ、ＲＶ／ＴＶ）的变化。结果显示，随低Ｏ２高ＣＯ２时间的延长，ｍＰＡＰ与ＥＴ均逐渐升高，二者呈良好正相关（ｒ＝０．７４２，Ｐ＜０．００１）。各实验组的ＲＶ／１００ｇＢＷ和ＲＶ／ＴＶ均高于对照组（Ｐ＜０．０１或０．００１）。血浆ＥＴ浓度与ＲＶ／１００ｇＢＷ呈良好正相关（ｒ＝０．５８６，Ｐ＜０．００１）。表明慢性常压低Ｏ２高ＣＯ２肺动脉高压大鼠血浆内皮素浓度增加，与肺动脉高压的形成及右心室肥大有关。

In pulmonary hypertension rats induced by hypoxia hypercapania we observed the changes of plasma ET concentration,mean pulmonary artery pressure(mPAP),right ventricular weight per 100g boby weight(RV/100g BW) and the ratio of right ventricular weight to total ventricular weight(RV/TV).Three groups were designed:Normal group(N,n=10),Two week group(T,n=10 exposed to normobaric hypoxic and hypercapnic environment 10 hours perday for two weeks).Four week group(F,n=10 in this environment for four weeks.Results showed:①mPAP and ET were gradually increased with hypoxia and hypercapnia time prolonged showing a positive correlation between them,r=0.742( P<0.001),②In T and F,the values of RV/100g BW、RV/TV were higher than those in N ( P<0.01 or 0.001).Plasma ET level was positively correlated with RV/100g BW,r=0.586( P<0.001)。Conclusion:The increase of Plasma ET concentration in pulmonary hypertension rats induced by chronic normobaric hypoxia and hypercapnia was related to the involement of pulmonary hypertension and right ventricular hypertrophy.