联合方案治疗儿童遗尿症临床疗效观察

The Clinical Study of Combined Treatment Plan for Nocturnal Enuresis in Children

目的：观察以盐酸奥昔布宁为主的联合治疗方案对儿童遗尿症（nocturnal enuresis，NE）的疗效。方法：将2006年10月-2007年10月收治的60例NE按就诊时间先后随机分为治疗组、对照组，每组30例。治疗组给予联合治疗方案，包括应用盐酸奥昔布宁、激光照射肾俞及三阴交穴、心理干预及膀胱功能训练；对照组仅口服盐酸奥昔布宁。疗程12周（其中激光治疗7天为一疗程），停止治疗后观察12周，共观察24周。比较两组治疗后近期疗效、远期疗效、起效时间及不良反应。结果：治疗后3个月，治疗组治愈率76．7％，对照组治愈率60．0％；6个月后随访，治疗组治愈率66．7％，对照组治愈率33．3％，两组比较差异均有显著性意义（P〈0．05，P〈0．01）。治疗组起效时间明显短于对照组（P〈0．05）。治疗过程中两组均无明显不良反应。结论：联合治疗方案治疗儿童NE，不但在短期内达到较高疗效，远期疗效亦佳。

Objective： To determine the efficacy of treatment for children＇s nocturnal enuresis by combined treatment plan with Choli- nolytic as the main drug. Methods： Sixty nocturnal enuresis patients admitted in our hospital during Oct. 2006 and Oct, 2007 were divided into two groups at random with 30 in each. The controls were treated with ditropan XL ＋ Laser treatment on Shenshu and Sanyinjiao points ＋ psychotherapy intervention ＋ bladder function training. And the corticosteroid group took cholinolytic orally. The course of treatment was twelve weeks,including 7 days of Laser treatment. The patients were observed for twelve weeks when the treatment was complete. The observation lasted for 24 weeks in all. The short-term and long-term cure effect, the time of taking effect and side-effect were compared. Results：Three months after the treatment, the cure rate in the corticosteroid group was 76.7% and 60.0% in the control group with a significant difference. Another follow-up was done 6 months later and it showed that the cure rate of the corticosteroid group was 66.7% ,while that of the control group was 33.3%, which showed a significant difference. The time of taking effect was much shorter in the corticosteroid group than in the control group（P 〈 0.05 ,P 〈 0.01 ）. In the course of the treatment, both groups were free from obvious side effects. Conclusion：Combined treatment plan for nocturnal enuresis（NE） in children can not only get high efficacy rate and cure rate in a short time,but also produce a good and long-term curative effect.