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微透析技术及其在经皮给药系统中的应用 被引量：10

Microdialysis Technique and Its Application in Transdermal Drug Delivery System
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摘要 综述了经皮微透析技术及其近年来在经皮给药系统中的应用,包括经皮吸收药物的药动学研究及生物利用度和生物等效性评价。 The cutaneous microdialysis and its application in transdermal drug delivery system, including pharmacokinetics, bioavailability and bioequivalence evaluation are reviewed.
作者 夏爱晓 冯健 李范珠
机构地区 浙江中医药大学药学院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2008年第5期378-382,共5页 Chinese Journal of Pharmaceuticals
关键词 经皮微透析技术 经皮给药系统 药动学 综述 cutaneous microdialysis technique transdermal drug delivery system pharmacokinetics review
分类号 R944.9 [医药卫生—药剂学]
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参考文献27

  • 1Anderson C, Andersson T, Molander M. Ethanol absorption across human skin measured by in vivo microdialysis technique [J]. Acta Derm Venereol, 1991, 71 (5) : 389-393.
  • 2Prausnitz MR, Mitragotri S, Langer R. Current status and future potential of transdermal drug delivery [J]. Nat Rev Drug Discov, 2004, 3 (2) : 115-24.
  • 3Kreilgaard M. Assessment of cutaneous drug delivery using microdialysis [J]. Adv Drug Dell Rev, 2002, 54(Suppl 1): S99-S121.
  • 4Schnetz E, Fartasch M. Microdialysis for the evaluation of penetration through the human skin barrier - a promising tool for future research [J]. Eur J Pharm Sci 2001, 12 (3): 165-174.
  • 5冯华,郑家润.微透析技术在皮肤科的应用[J].国外医学（皮肤性病学分册）,2004,30(2):75-77. 被引量：2
  • 6祝红达,胡晓.微透析技术在经皮给药系统评价中的应用[J].中国医院药学杂志,2007,27(2):240-242. 被引量：5
  • 7Mathy FX, Denet AR, Vroman B, et al. In vivo tolerance assessment of skin after insertion of subcutaneous and cutaneous microdialysis probes in the rat [J]. Skin Pharmacol Appl Skin Physiol, 2003, 16 (1) : 18-27.
  • 8Mathy FX, Ntivunwa D, Verbeeck RK, et al. Fluconazole distribution in rat dermis following intravenous and topical application: a microdialysis study [J]. J Pharm Sci, 2005, 94 (4) : 770-780.
  • 9Stagni G, O'Donnell D, Liu YJ, et al. Intradermal microdialysis: kinetics of iontophoretically delivered propranolol in forearm dermis [J]. J Controlled Release, 2000, 63 (3) : 331-339.
  • 10Zheng H, Shi LF, Hu JH. Pharmacokinetic study of free-form sinomenine in rat skin by microdialysis coupled with liquid chromatography-electrospray mass spectrometry [J]. Biomed Chromatogr, 2007, 21 (1) : 101-106.

二级参考文献61

  • 1Schnetz E, Fartasch M. Mierodialysis for the evaluation of penetration through the human skin barrier-a promising tool for future research? Eur J Pharm Sci, 2001, 12(3) :165 - 174.
  • 2Stahl M, Bouw R, Jackson A, et al. Human microdialysis. Curr Pharm Biotechnol, 2002, 3(2) :165 - 178.
  • 3Garrison KE, Pasas SA, Cooper JD, et al. A review of membrane sampling from biological tissues with applications in pharmacokinetics,metabolism and pharmacodynamics. Eur J Pharm Sei, 2002, 17( 1 -2):1 -12.
  • 4Groth L. Cutaneous microdialysis. Methodology and validation. Acta Derm Venereol Suppl ( Stockh). 1996. 197: 1 - 61.
  • 5Groth L, Jorgensen A, Serup J. Cutaneous microdialysis in the rat:insertion trauma and effect of anaesthesia studied by laser Doppler perfusion imaging and histamine release. Skin Pharmacol Appl Skin Physiol. 1998, 11 ( 3 ) : 125 - 132.
  • 6Borg N, Gotharson E, Benfeldt E, et al. Distribution to the skin of penciclovir after oral famciclovir administration in healthy volunteers:comparison of the suction blister technique and cutaneous microdialysis. Acta Derm Venereol, 1999, 79(4) :274 -277.
  • 7Sjogren F, Svensson C, Anderson C. Technical prerequisites for in vivo microdialysis determination of interleukin-6 in human dermis. Br J Dermatol, 2002, 146(3) :375 -382.
  • 8Leveque N, Robin S, Makki S, et al. Iron concentrations in human dermis assessed by microdialysis associated with atomic absorption soectrometry. Biol Pharm Bull, 2001 , 24( 1 ) :10 - 13.
  • 9Boschmann M, Murphy FP, Krueger JG. Microdialysis can detect age-related differences in glucose distribution within the dermis and subcutaneous adipose tissue. Dermatology, 2001, 202(3) :207.
  • 10Leveque N, Muret P, Mary. S, et al. Decrease in skin ascorbic acid concentration with age. Eur J Dermatol, 2002, 12 (4) : XXI - XXII.

共引文献15

同被引文献125

引证文献10

二级引证文献39

中国医药工业杂志
2008年 第5期

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