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循环肿瘤细胞检测及临床应用的研究进展 被引量：1

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摘要 研究发现,实体瘤患者外周血中存在循环肿瘤细胞。循环肿瘤细胞的检测有助于发现早期肿瘤患者的微转移,重新确定临床分期,监测患者术后肿瘤是否复发与转移,评估预后,选择个体化的治疗策略。由于存在循环肿瘤细胞检测方法、原发肿瘤细胞的不连续脱落、基因组的不稳定性及无效转移等诸多问题,循环肿瘤细胞检测的生物学意义和临床意义仍存在很大争议。本文综述了对实体瘤患者循环肿瘤细胞检测的方法和结果,并探讨当前肿瘤研究领域面临的问题和潜在的进展。
作者 黄同海 王正 李富荣
机构地区 暨南大学第二临床医学院深圳市人民医院胸外科 暨南大学第二临床医学院深圳市人民医院临床医学研究中心
出处 《肿瘤》 CAS CSCD 北大核心 2008年第5期450-452,共3页 Tumor
基金 国家科技攻关计划项目(编号:2003BA310A23)
关键词 肿瘤循环细胞 肿瘤转移 诊断技术和方法
分类号 R73-37 [医药卫生—肿瘤] R730.43 [医药卫生—肿瘤]
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参考文献20

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  • 2Romero-Laorden N, Olmos D, Fehm T, et al. Circulating and disseminated tumor cells in ovarian cancer: a systematic review[J]. Gynecol Oncol, 2014, 133(3):632-639.
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  • 5Waddell JN, Mullen DG, Orr BG, et al. Origin of broad polydispersion in functionalized dendrimers and its effects on cancer-cell binding affinity[J]. Phys Rev E Stat Nonlin Soft Matter Phys, 2010, 82(3):1-4.
  • 6Martinez-Veracoechea FJ, Frenkel D. Designing super selectivity inmultivalent nano-particle binding[J]. Proc Natl AcadSci U S A, 2011, 108(27):10963-10968.
  • 7Singh P, Gupta U, Asthana A, et al. Folate and folate-PEG- PAMAM dendrimers: synthesis, characterization, and targeted anticancer drug delivery potential in tumor bearing mice[J]. Bioconjug Chem, 2008, 19(11):2239-2252.
  • 8Yellepeddi VK, Vangara KK, Palakurthi S. Poly(amido)amine (PAMAM) dendrimer-cisplatin complexes for chemotherapy of cisplatin-resistant ovarian cancer cells[J]. Journal of Nanoparticle Research, 2013,15(9):1-15.
  • 9Yoo MK, Park IK, Lira HT, et al. Folate-PEG-superparamagnetic iron oxide nanoparticles for lung cancer imaging[J]. Actabiomaterialia, 2012, 8(8):3005-3013.
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肿瘤
2008年 第5期

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