经皮冠状动脉介入术血清C反应蛋白的变化

Changes of C Reactive Protein Level in Patients with Coronary Heart Disease after Percutaneous Coronary Intervention

目的:探讨经皮冠状动脉介入治疗术(PCI)后患者血清C反应蛋白(CRP)的变化。方法:随机选取行PCI的冠心病患者76例,分别于术前5 min、术后48 h、1月及6月测定血清CRP水平。结果:PCI术后48 h CRP水平明显高于术前5 min,有显著性差异(P<0.01);术后1月CRP水平较术前5 min明显下降(P<0.05)。结论:PCI术可能在短期内触发并加重冠状动脉炎症,术后1月恢复正常;术后CRP水平持续或再次升高,提示患者病情不稳定。

Objective： To observe the change of C reactive protein （CRP） level after percutaneous coronary intervention （PCI） and to explore the relationship between CRP and clinical state in patients with coronary heart disease（CHD）. Method Seventy - six patients with CHD were treated with PCI. The serum levels of CRP were measured by ELISA at 5 min before PCI, and the 48th hour, the first mouth, the sixth mouth after PCI. Results The serum level of CRP at the 48th hour after PCI was higher than that before PCI （ P 〈 0.01 ） , and the CRP level at the first mouth after PCI was lower than that before PCI（ P 〈 0.05 ）. However, the CRP level at the sixth month after PCI was higher than that before PCI （P 〈 0.05 ）. Conclusions PCI is likely to trigger and aggravate coronary artery inflammation in short - term and this change recovers to normal at the first month after PCI. The lesion in CHD may be unstable if the serum level of CRP continuously increases or elevates again.