短暂脑缺血发作患者红细胞与损伤内皮细胞粘附研究

Adhesion of Erythrocytes of Patients with Transient Ischemic Attack to Injured Endothelial Cells

采用流室系统定量地研究了短暂脑缺血发作患者红细胞与损伤内皮细胞的粘附特性．结果表明短暂脑缺血发作患者红细胞与损伤内皮细胞的粘附较红细胞与正常内皮细胞的粘附数目增多，强度增加，提示内皮细胞损伤促进了红细胞与内皮细胞粘附，而红细胞与内皮细胞粘附作用增强又加重了内皮细胞损伤，最终造成血流低灌注，导致神经功能缺损．同时也提示内皮细胞因素是红细胞与内皮细胞粘附的重要影响因素之一．

Adherence of erythrocytes of patients with transient ischemic attack(TIA) to human umbilical vein endothelial cells(HUVEC) treated with H2O2 were quantitatively studied in the now chamber system. The results showed that injured HUVECs enhanced the adherence of erythrocytes to endothelial cells in patients with TIA. The increased adhesion of erythrocytes to endothelial cells might promote the vascular damage. Consequently endotheli-um might play an important role in the increased adhesiveness of TIA RBC to endothelial cells.