摘要
作者研究具不同溶解度参数的介质对睾酮经皮渗透的影响，测定了药物在介质中的溶解度及通过大鼠皮肤的渗透速率。经Hildbrand法计算得到不同介质的溶解度参数（δv(n)），并由热力学公式进一步计算出药物在不同介质与皮肤间的分配系数（k）。结果显示，当介质的溶解度参数在一定范围内时，实验测得的药物渗透系数（p）的对数与药物理论分配系数（k）的对数有良好的相关性。
The effects of vehicles with different solubility parameters on the percutaneous penetration of testosterone were investigated. The solubility of testosterone in various vehicles and the fluxes through rat abdomen skin were determined. Values for experimental permeability coefficient(p) corresponding to the respective fluxes were also determined. These values were then compared with those for the respective partition coefficient(k) which were calculated from the known solubility parameters for the vehicles(δv(n)), testosterone(δi), and skin (δs). There was a good correlation between the values for theoretical logk-4.589 and experimental logp for the delivery oftestosterone.
关键词
睾酮
投药
经皮给药
渗透
溶解度
Testosterone/admin
Percutaneous administration
Skin
Osmosis
Solubility
Rat
