摘要
对２５０份母婴血清用ＥＬＩＳＡ法检测母血ＨＣＭＶ和ＨＳＶ－２ＩｇＧ与ＩｇＭ抗体及新生儿脐血ＩｇＭ抗体，拟了解孕妇激活感染的危险因素发现玉溪孕妇ＨＣＭＶ感染率为８６０％，而ＨＳＶ－２感染率仅为１８４％；孕妇与新生儿ＨＣＭＶ激活感染率分别为６４０％和２４０％；ＨＳＶ－２激活感染率分别为４８０％和２０％从文化程度分析小学、文盲组孕妇分娩的新生儿中ＩｇＭ抗体阳性率比中学以上组高孕妇怀孕胎次＞３次的ＲＲ（相对危险度）与怀１胎相比，ＨＣＭＶ的ＲＲ为５１，其分娩的新生儿为４７７；ＨＳＶ－２的ＲＲ为４７３，其分娩的新生儿为４７７孕妇有流产史和不良生产史者ＩｇＭ阳性率较正常或无生产史者其ＲＲ逐级增大孕妇的年龄、初潮年龄、职业与ＩｇＭ抗体阳性率关系不明显根据母婴间血清ＩｇＭ分布相关分析，ＨＣＭＶ感染的相关系数为０８９，ＨＳＶ－２感染的相关系数为０９１。结果提示ＨＣＭＶ，ＨＳＶ－２存在母婴间传播提出开展干预措施，降低先天性感染。
250 serum samples were detected by ELISA to determine HCMV and HSV-2IgG and IgM in the mother blood as well as IgM in the newborn umbilical cord blood so as to learn the risk factors of pregnant arousing infection. It was discovered that the infection rates were 86.0% for HVMV and 18.4% for HSV-2 among the pregnant women in Yuxi ; that HCVM arousing infection rates were 6.40% and 2.40% respectively for the pregnant and the newborn; and that HSV2-2 arousing infection rates were respectively 4.80% and 2.0% . In view of the education background, the newborn had a high IgM antibody positive rate in the mother group who were illiterate or only received elementary education thant in the group composed of mothers with educations of or above the secondary level. When pregnancy frequency > 3 was compared with pregnancy frequency = 1 , relevant risk (RR) was 5.1 for HCMV and 4.77 for HCVM newborn; 4.78 for HSV-2 and 4.77 for HSV-2 newborn. IgM positive rate was higher in the pregnant with either abortion history or unhealthy birth history than in the pregnant without abortion history or birth history. The age, menarche age and occupation all had no obvious relationship with IgM positive rate. According to the correlation analysis of serum IgM distribution from mother and infant, the correlation coefficient was 0.99 for HCMV infection and 0.91 for HSV-2 infection. This suggested that HCMV and HSV-2 do spread between mother and infant. It is certainly important to take interference measures, to reduce inborn infection and to improve population quality.
出处
《昆明医学院学报》
1997年第4期10-13,共4页
Journal of Kunming Medical College
