摘要
目的观察阿托伐他汀治疗冠心病慢性心力衰竭患者的疗效。方法将103例慢性心力衰竭患者随机分为对照组和治疗组,观察治疗前后NYHA心功能分级,同时以超声心动图检测左室舒张末期内径(LVED)、左室收缩末期内径(LVES)、左室射血分数(LVEF)及E/A比值;采用酶联免疫吸附法测定其治疗前后血浆中肿瘤坏死因数-α(TNF-α)、白细胞介素-6(IL-6);并以化学发光法测定B型利钠肽(BNP)水平等指标的变化来评估治疗效果。结果180 d后,阿托伐他汀治疗组与对照组比较LVEF、LVES、LVED、E/A存在统计学意义(P<0.05);TNF-αI、L-6、BNP均明显下降。结论在常规治疗的基础上加用阿托伐他汀治疗慢性充血性心力衰竭;有更好的临床疗效。
Objective To investigate the effects of atorvastatin on patients suffering from chronic congestive heart failure（CHF）. Methods One hundred and thirty two CHF patients were randomly divided into routine control group, atorvastatin treated group. The changes of left ventricular end diastolic diameter（LVED）,left ventricular end contract surface（LVES）,left ventricular ejection fraction（LVEF） ,and cardiac function（NYHA class）were observed before and after therapy. The plasma levels of TNF2a and IL26 were measured by enzyme-linked immunosorbent assay （ELISA）before management and were remeasured after therapy. At the same time the concentra- tion of brain natriuretic peptide（BNP）were determined with chemiluminescent method. Results One hundred and eighty days later, there was a significant statistical differences in LVEF, LVES, E/A and BNP between atorvastatin group and routine control group（P〈0. 05） ,and the decreasing extent of TNF-α, IL-6, and BNP in the atorvastatin treated group was greater than that in the conventional group. Conclusion The treatment of conventional plus atorvastatin might generate better clinical efficacy in treating patients with CHF.
出处
《实用临床医学（江西）》
CAS
2008年第4期23-25,27,共4页
Practical Clinical Medicine
