柯萨奇B组病毒所致神经系统病变临床探讨

A Clinical Study of Lesions of the Nervous System Caused by Coxsackie B Virus

目的柯萨奇B组病毒（CoxsackieBvirusesCBV）所致神经系统病变目前报道较少，其实并非少见。主要因其感染后多系统损害症状复杂，很难使人们确诊为神经系统病变，如不早期确诊及时治疗，个别病人可导致失明或致残。方法所有可疑本病患者均经CBV抗体IgM、IgGI－Ⅳ型测定，采用酶联免疫吸附试验（ELISA），用（CBVI－Ⅳ）抗原分别检查患者血清中的抗体（包括IgM和IgG）IgMI：100·IgG1；800或1：1600视为阳性。结果9例病人IgM1：100、IgG1：1600阳性，5例IgM（－）、IgG1：1600阳性确诊为柯萨奇B组病毒感染。结论以上病人均给抗病毒和脑细胞活化剂治疗一个月，临床体征消失，头颅CT扫描转正常。临床实践证明病原学血清诊断是唯一先决条件，病毒特异性抗体检测已是公认的一种可靠快速可取的诊断方法。

The lesions of the nervous system caused by Coxsackie B Virus (CBV) have been rarely reported so far,but actually it is not rare.Because of the complexity of clinical manifestation after infection,it is very difficult to make a definite diagnosis for these lesions.If the patients were not early diagnosed and treated in time,some of them may cause losing of sight and other disabilities.Measurements of IgM,IgGⅠ-Ⅳ CBV antibody were done with enzymolinked immunosorbent analysis (ELISA) .The antibodies were determined in sera by Ⅰ-Ⅳ antigens re-spectively.IgM1: 100,IgG1: 800 or 1: 1600 were regardedas positive reaction.9 of them showed positive reac-tion with IgM1:100,IgG1: 1600,5 of them IgM (-),IgG1: 1600 (+ ),by which CBV inflection was defi-nite.The diagnosed patients were treated one month with antivirotics and cerebral cytoactivators.Then the clini-cal for symptoms disappeared and cranial CT scan became normal.The clinical practice proved that the serum tests of the etiology is the unique precondition for diagnosis of the lesions.The determinations of special antibody have been acknowledged as a rapidly reliable measurement tor diagnosis.