长期口服卡托普利对高血压病患者预后的影响

The Effect of long-term Treatment with Captopril on the Prognosis of Hypertensive Patients.

探讨长期服用卡托普利对高血压病的改善作用。方法将２４５例Ⅰ、Ⅱ期高血压病患者按服药情况分为卡托普利和其它药物组，口服卡托普利或其它抗高血压药物平均（５．１±０．６）ａ。结果长期服用卡托普利不仅能使血压持续稳定在正常水平，而且左室肥厚逆转，心脏舒张功能改善，眼底病变好转（Ｐ＜０．０１），尿蛋白排泄量下降（Ｐ＜０．０１），且无脑卒中发生（Ｐ＜０．０５），而对照组上述指标均较服药前有加重趋势，其加重程度和观察时间呈正相关（Ｐ＜０．０１）。

Objective The aim of this study was to evaluate the long-term therapeutic benefit of captopril for the main complication of hypertension. Method Two hundred and forty-five essential hypertensive patients in stage Ⅰ or Ⅱ were divided into captopril group and noncaptopril group,according to the drugs used and investigated for (5.1±0.6) years. Results Long-term treatment with captopril not only decreased blood pressure to a satisfactory level,but also improved left ventricular hypertrophy,decreased albuminuria ( P < 0.001 ),reversed hypertensive retinopathy ( P <0.01).There was no stroke in the captopril group.There was an exacerbation of the changes abovementioned in noncaptopril group and the exacerbation correlated positively to the duration of observation ( P <0.01). Conclusion Long-term treatment with captopril improves the prognosis of hypertensive patients.