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WIF-1研究进展 被引量：2

Progress on WIF-1 Research
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摘要 WIF-1是Wnt信号通路上的拮抗物之一,可以阻断Wnt的经典通路和非经典通路。目前在人类多种肿瘤的研究发现WIF-1表达异常。WIF-1(Wnt inhibitory factor-1),sFRP(Frizzled related protein)和CER(Cerberus)属于Wnt拮抗物家族,通过直接与Wnt蛋白相连从而阻止Wnt与受体蛋白复合物相连,使细胞质中的β-catenin由于磷酸化而不能积累,进而阻断了经典通路和非经典通路。WIF-1可能与中胚层的发生以及肿瘤细胞的生长分化有关。Wnt家族其他成员已经被证实与早期冠心病、Ⅱ型糖尿病、肥胖症、骨质疏松症等相关。因此了解WIF-1在通路上的更多信息,解释WIF-1调节Wnt信号通路的机理和过程,为疾病治疗和预防以及药物开发提供新的方法。 WIF-1 is one of the antagonists of Wnt signal pathway and it inhibites Wnt canonal pathway and noncanonal pathway. At present, aberrant WIF-1 activation is normal in several human tumors. WIF-1 （Wnt inhibitory factor-1 ）, sFRP （Frizzled related protein）and CER（Cerberus） are all members of Wnt antagonists, which bind to Wnt directly and inhibit the link with their receptors, and as a result, the accumulation of β-catenin is reduced and canonal and noncanonal pathway are inhibited. WIF-1 is perhaps related to mesoderm development and tumor cell growth and differentiation. Other members of Wnt family have been confirmed to associate with early coronary heart disease, diabetes Ⅱ , obesity, osteoporosis and so on. The more we learn about WIF-1 in Wnt signal pathway, the more we know mechanism and function in signal pathway and new methods in diseases cure and medicine development.
作者 周文君 张连峰
机构地区 中国医学科学院医学实验动物研究所
出处 《中国比较医学杂志》 CAS 2008年第5期21-23,36,共4页 Chinese Journal of Comparative Medicine
关键词 WNT WIF-1 信号传导 Wnt WIF-1 Signal transduction
分类号 R-332 [医药卫生]
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参考文献19

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同被引文献35

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中国比较医学杂志
2008年 第5期

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