摘要
作者报道了从各型胃病患者胃粘膜中分离的112株幽门螺杆菌,用聚丙烯酰胺凝胶电泳(SDS-PAGE)及Westernblots分析,可将HP菌分为Ⅰ-Ⅳ型,而其中Ⅳ型又分为Ⅳ-1至Ⅳ-5五个亚型;不同HP间存在明显的蛋白抗原差异和LPS/LOS的表达差异;为今后开展HP疫苗研究提供了重要线索。
Helicobacter pylori, an organism recently described in association with gastritis and pepticlesions. The degree of relationship between these micro - organisms was studied on molecular level usingSDS- PAGE protein profiles and immunoblot patterns. Study on a total of 112 lysates of H. pylorishowed some differences in protein patterns of different H. pylori strains. However, the difference becamemore apparent when studied by immunoblot analysis. According to SDS - PAGE protein, strains isolatedfrom gastric mucous of the patients were identified as types Ⅰ-Ⅳ, while type Ⅳ can be further classifiedas sub-type Ⅳ -Ⅰto Ⅳ-5 analysis of SDS - PAGE protein patterns proved to be an excellent method ofcharacterizing those H. pylori, different from traditional methods.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
1997年第6期338-340,共3页
Chinese Journal of Epidemiology
基金
国家自然科学基金